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        基于互穿網絡技術構筑的氧化海藻酸鈉/纖維素納米晶/聚丙烯酰胺-明膠復合水凝膠與性能
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        1. 海南師范大學 熱帶藥用植物化學教育部重點實驗室,海南 ???571158;2. ??谑刑烊桓叻肿庸δ懿?料重點實驗室,海南 ???571158;3. 海南省水環境污染治理與資源化重點實驗室,海南 ???571158

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        Construction and Property of Oxidized Sodium Alginate/Cellulose Nanocrystal/Polyacrylamide-Gelatin Composite Hydrogel Based on Interpenetrating Network Technology
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        1. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, Hainan, China; 2. Key Laboratory of Natural Polymer Functional Material of Haikou City, Haikou 571158, Hainan, China; 3. Key Laboratory of Water Pollution Treatment and Resource Reuse of Hainan Province, Haikou 571158, Hainan, China

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          摘要:

          為了提高海藻酸鹽水凝膠的生物應用性,以氧化海藻酸鈉(OSA)為原料,采用互穿網絡技術、纖維素 納米晶(CNCs)補強和明膠(GT)表面覆積相結合的方法構建了 OSA/CNCs/PAM-GT 復合水凝膠(其中,PAM 為聚丙烯酰胺)。通過 FTIR、TGA、XRD、SEM、溶脹性和降解性實驗以及細胞相容性測試考察了 CNCs 含量 對 OSA/CNCs/PAM-GT 復合水凝膠結構和性能的影響。結果表明,CNCs 能夠與基體中的聚合物產生相互作用 力。隨著 CNCs 含量的增加,OSA/CNCs/PAM-GT 復合水凝膠的孔隙率下降,力學性能提高,其溶脹率隨 CNCs 含量增加呈下降趨勢(下降幅度較?。┒锝到饴食噬仙厔?,說明 CNCs 能夠在一定程度上調控復合水凝 膠的物化性能。OSA/CNCs/PAM-GT 復合水凝膠展現出較好的細胞黏附、增殖和分化性能。當 CNCs 的含量為 0.5%時(以 OSA 溶液質量為基準,下同),人骨瘤(MG63)細胞增殖效果最佳,而 CNCs 的含量為 1.5%時,MG63 細胞分化效果最顯著。

          Abstract:

          To improve the bio-applicability of alginate hydrogel, the composite hydrogels of oxidized sodium alginate (OSA)/cellulose nanocarrier (CNCs)/ polyacrylamide-gelatin (PAM-GT) were constructed from combination of interpenetrating network technology, CNCs reinforcement and GT surface deposition with OSA. The effects of CNCs dosage on the structure and properties of OSA/CNCs/PAM-GT composite hydrogels were analyzed by FTIR, TGA, XRD, SEM, swelling and degradability experiments as well as cytocompatibility tests. The results showed that CNCs could interact with the polymers in the matrix. As the dosage of CNCs increased, the composite hydrogel exhibited a decreased porosity, enhanced mechanical strength and biodegradability, and a slightly reduced swelling, indicating that CNCs could regulate the physicochemical properties of the composite hydrogels to a certain extent. Meanwhile, the composite hydrogels displayed good cell adhesion, proliferation and differentiation properties. When the dosage of CNCs was 0.5%(based on the mass of OSA solution, the same below), the composite hydrogel showed the best cell proliferation activity for MG63 cells, while displayed the most significant cell differentiation activity when the dosage of CNCs was 1.5%.

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        陳秀瓊,廖雨青,王洪財,李東澤,顏慧瓊,林強.基于互穿網絡技術構筑的氧化海藻酸鈉/纖維素納米晶/聚丙烯酰胺-明膠復合水凝膠與性能[J].精細化工,2023,40(6):

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        • 收稿日期:2022-08-05
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        • 在線發布日期: 2023-06-28
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