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        硼碳氮納米管的制備及靶向遞送阿霉素的抗腫瘤性能
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        1.海南大學 材料科學與工程學院;2.華中科技大學 材料科學與工程學院

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        海南省基礎與應用基礎研究計劃(自然科學領域)高層次人才項目(2019RC029)


        Preparation of boron carbonitride nanotubes using as targeted delivery vehicle for DOX and the antitumor performance
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        1.School of Materials Science and Engineering,Hainan University;2.School of Materials Science and Engineering,Huazhong University of Science and Technology

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        海南省基礎與應用基礎研究計劃(自然科學領域)高層次人才項目(2019RC029)

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          摘要:

          采用納米材料作為化療藥物的遞送載體,能夠降低藥物的毒副作用。本文通過改進固相反應法制備了硼碳氮納米管(BCNNTs),并采用葉酸(FA)對BCNNTs進行功能化修飾,用于負載抗腫瘤藥物阿霉素(DOX),構建了FA-BCNNTs-DOX 靶向給藥系統。FTIR和UV-Vis分析結果表明DOX在FA-BCNNTs上的負載,其負載量為87.11 μg/mg。體外細胞毒性實驗結果證實了FA-BCNNTs-DOX系統的抗腫瘤活性明顯優于未采用納米管負載的游離DOX和未經FA修飾的BCNNTs-DOX,且FA-BCNNTs-DOX和BCNNTs-DOX均具有pH響應性釋放特點,這非常有利于DOX生物利用度的提高,減少其對正常細胞的損傷。另外,細胞攝取實驗表明FA-BCNNTs-DOX是通過葉酸受體介導的內吞作用進入癌細胞,有效提高了藥物的遞送效率。

          Abstract:

          Using nanomaterials as delivery vehicles of chemotherapeutic drugs enable to reduce their side effects. In this work, BCNNTs were prepared via an improved solid-state reaction method, which were then functionalized by folate (FA) to load doxorubicin (DOX), thereby building a targeted drug delivery system of FA-BCNNTs-DOX. FTIR and UV-Vis analysis results revealed the loading of DOX on FA-BCNNTs, accompanied with the capacity of 87.11 μg/mg. In vitro cytotoxicity test indicated that the antitumor activity of FA-BCNNTs-DOX is significantly higher than those of free DOX and BCNNTs-DOX. Furthermore, FA-BCNNTs-DOX and BCNNTs-DOX were found to possess pH-responsive release characteristic, which helps to improve the bioavailability of DOX and reduce the damage to healthy cells. In addition, cellular uptake research indicated that FA-BCNNTs-DOX entered cancer cells through folate receptor-mediated endocytosis, which greatly enhanced the drug delivery efficiency.

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        引用本文

        楊歡,李佳鑫,顧水丹,駱麗杰,陳擁軍.硼碳氮納米管的制備及靶向遞送阿霉素的抗腫瘤性能[J].精細化工,2023,40(6):

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        歷史
        • 收稿日期:2022-10-17
        • 最后修改日期:2022-12-05
        • 錄用日期:2022-12-08
        • 在線發布日期: 2023-05-11
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