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        GMA接枝海藻酸鈉的光交聯協同二價金屬陽離子配位交聯互穿網絡凝膠的制備及釋藥性能評價
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        西北大學 化工學院

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        陜西省自然科學基礎研究計劃項目(2018JM2037,2020JQ-609,2023-JC-YB-672),中國博士后基金(2020M683701XB)


        Preparation and evaluation of drug release properties of GMA-grafted sodium alginate photo-crosslinking with bivalent metal cationic coordination crosslinking interpenetrating network gels
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        School of Chemical Engineering Northwest University

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          摘要:

          用甲基丙烯酸縮水甘油酯(GMA)對海藻酸鈉(Na-Alg)進行接枝改性得到Alg-GMA,利用光引發自由基聚合協同二價陽離子(M2+,M代表Ca和Ba)配位交聯作用,可調節海藻酸鹽水凝膠的結構與性能。1HNMR結果表明,Alg-GMA中出現了與GMA相關的氫信號。在光引發劑Irgacure 2959存在下,Alg-GMA經波長365 nm紫外光照射90s即可快速形成Na-Alg-GMA水凝膠。SEM和壓縮應力-應變結果顯示,Ca2+和Ba2+具有調節GMA接枝光交聯海藻酸鹽凝膠結構與性能的作用,這可能與Ca2+的平面四方形構型dsp2軌道雜化方式和Ba2+的正八面體構型d2sp3軌道雜化方式有關。體外釋放實驗結果表明,Ca-Alg-GMA和Ba-Alg-GMA均具有腸道靶向釋放藥物能力。溶血率和MTT實驗結果顯示,Ca-Alg-GMA和Ba-Alg-GMA具有血液相容性好、細胞毒性低的特點。該研究拓展了基于海藻酸鹽的新材料制備方法及其在生物醫藥領域中的應用空間,并提供了理論依據和實驗支持。

          Abstract:

          In this paper, sodium alginate (Na-Alg) was grafted with glycidyl methacrylate (GMA), and the structure and properties of alginate hydrogel were adjusted by photoinitiated radical polymerization and bivalent cationic (M2+,M represents Ca or Ba) coordination crosslinking. The results of 1H NMR analysis showed that the hydrogen signal associated with GMA appeared in Alg-GMA. In the presence of photoinitiator Irgacure 2959, Alg-GMA can form hydrogel rapidly by irradiation of ultraviolet light with wavelength of 365nm in 90s. The results of SEM and compressive stress-strain showed that Ca2+ and Ba2+ could regulate the structure and properties of the photo-crosslinking alginate gel grafted by GMA, which may be related to the dsp2 hybridization mode of Ca2+ in the planar quadrate configuration and d2sp3 hybridization mode of Ba2+ in the regular octahedral configuration. The results of in vitro release experiments showed that both Ca-Alg-GMA and Ba-Alg-GMA had the ability of intestinal targeted drug release. The hemolysis rate and MTT test showed that Ca-Alg-GMA and Ba-Alg-GMA had good blood compatibility and low cytotoxicity. This study expands the preparation method of new materials based on alginate and its application space in the field of biomedicine, and provides theoretical basis and experimental support.

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        陳欣,曹波,溫惠云,黃賽朋,郭鵬琦,薛偉明. GMA接枝海藻酸鈉的光交聯協同二價金屬陽離子配位交聯互穿網絡凝膠的制備及釋藥性能評價[J].精細化工,2023,40(7):

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        • 收稿日期:2022-11-22
        • 最后修改日期:2023-01-04
        • 錄用日期:2023-01-05
        • 在線發布日期: 2023-06-12
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